Tau aggregation is a hallmark feature in a subset of patients with frontotemporal dementia
(FTD). Early and selective loss of von Economo neurons (VENs) and fork cells within the …

Objective: To identify antemortem CSF diagnostic biomarkers that can potentially distinguish
between the 2 main causes of frontotemporal lobar degeneration (FTLD), ie, FTLD with TDP …

Abstract Recently, TDP-43, a 43 kDa nuclear TAR DNA-binding protein, was identified as
the major disease protein in frontotemporal lobar degeneration with ubiquitinated inclusions …

Frontotemporal dementia linked to chromosome 3 (FTD-3) is a very rare disease described
in a large Danish family [1] and also in an unrelated Belgian patient with familial FTD [12]. A …

Frontotemporal dementia is accompanied by motor neuron disease (FTD+ MND) in∼ 10%
of cases. There is accumulating evidence for a clinicopathological overlap between FTD and …

A large Danish family has previously been reported in which autosomal dominant
frontotemporal dementia (FTD) is genetically linked to chromosome 3 (FTD-3). A mutation …

Frontotemporal lobar degeneration (FTLD) represents a group of neurodegenerative brain
diseases with highly heterogeneous clinical, neuropathological and genetic characteristics …

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) can typically be
categorized into one of four distinct histopathologic patterns of TDP-43 pathology, types A to …

The frontotemporal dementias (FTDs) are a heterogeneous group of neurodegenerative
disorders that are characterized clinically by dementia, personality changes, language …

Hereditary frontotemporal dementia (FTD) is an autosomal dominant neurodegenerative
disorder that is associated with mutations in the tau gene and with the pathological …