Pulmonary surfactants consist of phospholipids and the hydrophobic proteins surfactant
protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the …

In healthy individuals breathing is an effortless process that occurs with a frequency of
approximately 25,000 cycledday. The work of breathing is kept to a minimum by the …

Elucidation of the structure and function of the hydrophobic surfactant protein (SP-B) and the
SP-B gene has provided critical insight into surfactant homeostasis and control of respiratory …

Pulmonary surfactant lowers surface tension in the lung. Its deficiency leads to the severe
physiologic abnormalities seen in the respiratory distress syndrome. The hydrophobic …

Pulmonary surfactant is a lipid-protein complex that promotes alveolar stability by lowering
the surface tension at the air-fluid interface in the peripheral air spaces. A group of …

This article starts with a brief account of the history of research on pulmonary surfactant. We
will then discuss the morphological aspects and composition of the pulmonary surfactant …

Surfactant protein A (SP-A) is a highly ordered, oligomeric glycoprotein that is secreted into
the airspaces of the lung by the pulmonary epithelium. The in vitro activities of protein …

The past few years have witnessed a rapid expansion in our knowledge of pulmonary
surfactant with specific emphasis on the nature, function, and molecular biology of the …

The production of pulmonary surfactant is necessary to maintain alveolar stability and
normal lung function. Mutations in three different genes important for surfactant production …

Mutations in the surfactant protein (SP)-C gene are responsible for familial and sporadic
interstitial lung disease (ILD). The consequences of such mutations on pulmonary surfactant …