PURPOSE AND METHODS Between January 1981 and June 1993, 137 children and
adolescents were each treated at the Institut Gustave Roussy for an initially nonmetastatic …

In this retrospective analysis, we report on the detailed management of 33 recurrent
osteosarcoma patients from a population of 81 adolescents and adults previously treated …

Background Approximately one‐third of patients with osteosarcoma who have a complete
response to their initial treatment can be expected to relapse. It is important to define what …

The aim of this study was to identify predictive factors of late relapse in nonmetastatic
osteosarcoma patients treated at the Rizzoli Institute from 1983 to 1997. Clinical features of …

Background With the introduction of intensive high‐dose chemotherapy for the treatment of
osteosarcoma, changes in the pattern of metastases observed at relapse have been …

Ninety-eight pediatric patients were treated with three separate protocols (Treatment and
investigation of Osteosarcoma [TIOS] I, II, and III) and 47 developed recurrent disease …

BACKGROUND Despite improvements in therapy for osteosarcoma, approximately 4–10%
of patients experience a local recurrence and have a poor prognosis. METHODS The …

BACKGROUND The objective of this report was to estimate long‐term outcome and
prognostic factors in children and adolescents who presented with metastatic osteosarcoma …

BACKGROUND The goal of the current study was to define the clinical features and
outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with …

Long‐term disease‐free survival in patients with localised osteosarcoma treated in large
multicentre randomised trials is over 50%. Most relapses occur early, usually within 2–3 …