Pancreatic cancer is one of the leading causes of death worldwide among all cancer types
due to difficulty detecting in early-stages of disease. Poor understanding of the mediators …

Pancreatic cancer is a leading cause of mortality worldwide due to the difficulty of detecting
early-stage disease and our poor understanding of the mediators that drive progression of …

Pancreatic cancer (PC) remains one of the leading causes of cancer-associated deaths in
the US due to its highly aggressive nature and lack of effective treatments. Pancreatic tumors …

Objective: As people continue to succumb to the progression of various forms of cancer, the
extreme lethal nature of pancreatic cancer in particular suggests that new therapeutic targets …

In solid tumors, the development of vasculature is, to some extent, slower than the
proliferation of the different types of cells that form the tissue, both cancer and stroma cells …

Pancreatic cancer is a lethal malignancy with an extremely poor prognosis. Although many
genes and noncoding RNAs have been found to regulate its progression, more regulators …

Rationale: Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) is an endoplasmic
reticulum (ER) luminal glycoprotein that has a role in the formation of disulfide bonds of …

Hypoxia is a key feature of solid tumors, associated with disease aggressiveness and poor
outcome. Besides undergoing broad intracellular molecular and metabolic adaptations …

The solid tumor microenvironment possesses a hypoxic condition, which promotes
aggressiveness and resistance to therapies. Hypoxic tumor cells undergo broadly metabolic …

Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with
aggressiveness and poor patient outcomes. A continuous interference between cancer cells …