Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with
aggressiveness and poor patient outcomes. A continuous interference between cancer cells …

Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Purpose Hypoxia is a major regulator of angiogenesis and always influences the release of
exosomes in various types of tumors. The present review aimed to assess the role of …

Prostate cancer (PCA) is the leading malignancy in men and the second leading cause of
cancer-related deaths. Hypoxia (low O 2 condition) is considered an early event in prostate …

Background Exosomes are nanovesicles secreted by tumour cells which have roles in
paracrine signalling during tumour progression, including tumour-stromal interactions …

Recent studies have found that hypoxia contributes to tumor progression and drug
resistance by inducing the secretion of exosomes. However, the mechanism underlying this …

Pancreatic cancer is a highly lethal malignancy and molecular mechanisms underlying its
pathobiology are not yet well understood. Pancreatic tumors are characterized by a poor …

Exosomes are structurally and functionally pleiotropic nano-sized (~ 30–150 nm in diameter)
extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors with
an overall five-year survival rate of that has only just reached 10%. The tumor …

Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …