One of the key factors that correlates with poor survival of patients with pancreatic cancer is
the extent of hypoxic areas within the tumor tissue. The adaptation of pancreatic cancer cells …

Pancreatic cancer (PC) is one of the deadliest malignancies. The high mortality rate of PC
largely results from delayed diagnosis and early metastasis. Therefore, identifying novel …

Hypoxia is a critical feature of solid tumors and is considered to be a key factor in promoting
tumorigenesis and progression. Beyond inducing metabolic reprogramming of tumor cells to …

Tumor cells express a high quantity of exosomes packaged with unique cargos under
hypoxia, an important characteristic feature in solid tumors. These hypoxic tumor-derived …

Pancreatic adenocarcinoma is the deadliest cancer and currently the fourth most frequent
cause of cancer-related deaths. The disease is characterized by the lack of early symptoms …

Epithelial-to-mesenchymal transition (EMT) is a classical cellular plasticity process induced
by various cell-intrinsic and-extrinsic triggers. Although prominent factors, such as TGFβ …

Background Tumor hypoxia is associated with metastasis and resistance to chemotherapy
and radiotherapy. Genes involved in oxygen-sensing are clinically relevant and have …

Exosomes are emerging as important mediators of the cross-talk between tumor cells and
the microenvironment. However, the mechanisms by which exosomes modulate tumor …

Background Pancreatic cancer (PC) is among the most aggressive types of cancer. Hypoxia
has been identified as a key risk factor for cancer progression. The forkhead box (FOX) …