Protein folding in the endoplasmic reticulum is an oxidative process that relies on protein
disulfide isomerase (PDI) and endoplasmic reticulum oxidase 1 (ERO1). Over 30% of …

Exosomes play important roles in cell-cell communication, and are likely mediators of the
metastatic cascade in cancer. This study examined the role of exosomes in pancreatic …

Pancreatic tumors are highly desmoplastic and poorly‐vascularized, and therefore must
develop adaptive mechanisms to sustain their survival under hypoxic condition. Extracellular …

Abstract Background and Aims: Hepatocellular carcinoma (HCC), a prevalent solid organ
malignancy, is intricately linked to the glycolytic enzyme Alpha-enolase (ENO1). ENO1's …

Background Intratumoral oxidative stress (OS) has been associated with the progression of
various tumors. However, OS has not been considered a candidate therapeutic target for …

Hypoxia, or low oxygen tension, is a major regulator of tumor development and
aggressiveness. However, how cancer cells adapt to hypoxia and communicate with their …

Metastasis remains the leading cause of cancer-related deaths. To date, there are no
specific treatments targeting disseminated disease. New therapeutic options will become …

Background Hypoxia is a major regulator of tumor aggressiveness and metastasis in cancer
progression. Exosomes (exos) play an important role in the communication between lung …

Ewing's sarcoma (EWS) is a malignant tumor that primarily develops in children and
adolescents. The main driver in EWS tumor progression is the result of a chromosomal …

Simple Summary Most solid tumours, including melanoma (skin cancer), are riddled with
areas lacking adequate oxygen supply due to insufficient vasculature. Cancer cells in these …