We have shown that the dominance of CD8+ T cells expressing TCR Vβ17 in the adult HLA-
A* 0201-restricted influenza A/M158–66-specific response is acquired following first antigen …

During acute human viral infections, such as influenza A, specific cytotoxic T lymphocytes
(CTL) are generated which aid virus clearance. We have observed that in HLA-A* 0201+ …

The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL)
response is important in the clearance of viral infections in humans. After influenza A …

The H-2D b-restricted CD8 T cell immune response to influenza A is directed at two well-
described epitopes, nucleoprotein 366 (NP366) and acid polymerase 224 (PA224). The …

Eight HLA B7‐restricted influenza A virus nucleoprotein 383–391‐specific cytotoxic T
lymphocyte (CTL) clones were obtained from three unrelated donors following natural …

In the present study, the recognition of epitope variants of influenza A viruses by human CTL
was investigated. To this end, human CD8+ CTL clones, specific for natural variants of the …

Recent studies have demonstrated biased usage of TCR Vβ17 and a high degree of
diversity in Jβ usage within the influenza virus matrix epitope (M. 58-66)-specific CTL …

Cytokine polyfunctionality has recently emerged as a correlate of effective CTL immunity to
viruses and tumors. Although the determinants of polyfunctionality remain unclear, there are …

Early studies of influenza virus-specific CD8+ T cell-mediated immunity indicated that the
level of CTL activity associated with H2D b is greatly diminished in mice that also express …

The spectrum of TCR usage has been analyzed for virus-specific CD8+ T cells isolated from
the regional mediastinal lymph modes and from the lung by bronchoalveolar lavage (BAL) of …