Alternative splicing (AS) contributes to proteome diversity. As splicing occurs
cotranscriptionally, epigenetic determinants such as DNA methylation likely play a part in …

Alternative splicing is a molecular mechanism that produces multiple proteins from a single
gene, and is thought to produce variety in proteins translated from a limited number of …

Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

Alternative splicing is now commonly thought to affect more than half of all human genes.
Recent studies have investigated not only the scope but also the biological impact of …

Recently, genomics analyses have demonstrated that alternative splicing is widespread in
mammalian genomes (30–60% of genes reported to have multiple isoforms), and may be …

Alternative pre-mRNA splicing affects a majority of human genes and plays important roles
in development and disease. Alternative splicing (AS) events conserved since the …

Alternative splicing is a major contributor to genomic complexity, disease, and development.
Previous studies have captured some of the characteristics that distinguish alternative …

Background Alternative pre-mRNA splicing (AS) is widely used by higher eukaryotes to
generate different protein isoforms in specific cell or tissue types. To compare AS events …

High-throughput RNA sequencing (RNA-seq) has revealed an enormous complexity of
alternative splicing (AS) across diverse cell and tissue types. However, it is currently …

Background While alternative splicing (AS) contributes greatly to protein diversities, the
relationship between various types of AS and epigenetic factors remains largely unknown …