A mutual relationship exists between immune activation and mechanisms of thrombus
formation. In particular, elements of the innate immune response such as the complement …

The coagulation and complement systems are ancestrally related enzymatic cascades of the
blood. Although their primary purposes have diverged over the past few hundred million …

A wealth of evidence indicates a fundamental role for inflammation in the pathogenesis of
cardiovascular disease (CVD), contributing to the development and progression of …

Coagulation and innate immunity are linked evolutionary processes that orchestrate the host
defence against invading pathogens and injury. The complement system is integral to innate …

The complement and hemostatic systems are complex systems, and both involve enzymatic
cascades, regulators, and cell components—platelets, endothelial cells, and immune cells …

The parallel expression of activation products of the coagulation, fibrinolysis, and
complement systems has long been observed in both clinical and experimental settings …

The complement system, originally classified as part of innate immunity, is a tightly self-
regulated system consisting of liquid phase, cell surface, and intracellular proteins. In the …

The complement system is a versatile part of our immune system. Various intersection points
of complement with other cells and molecules of the immune response are well described …

Platelets play an essential role in maintaining homeostasis in the circulatory system after an
injury by forming a platelet thrombus, but they also occupy a central node in the …

The complement system was discovered a century ago as a potent defense cascade of
innate immunity. After its first description, continuous experimental and clinical research was …