Natural killer (NK) cell immunotherapies for cancer can complement existing T cell therapies
while benefiting from advancements already made in the immunotherapy field. For NK cell …

Natural killer (NK) cells play a crucial role in host immunity by detecting cells that
downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in …

The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the
door to a new generation of regenerative medicine research. Among PSCs, the donors …

Adoptive immunotherapy using immune effector cells has revolutionized cancer treatments
with approval of two autologous chimeric antigen receptor (CAR) T cell therapies by the US …

Adoptive cell therapy is a rapidly advancing approach to cancer immunotherapy that seeks
to facilitate antitumor responses by introducing potent effector cells into the tumor …

Background aims Traditionally, natural killer (NK) cells are sourced from the peripheral
blood of donors―a laborious and highly donor-specific process. Processes for generating …

Highlights•hPSCs are achievable to produce universal off-the-shelf NK cells.•Fully defined
protocols have been developed for NK cell induction.•CARs have been designed and …

Natural killer (NK) cells are powerful immune effectors whose antitumor activity is regulated
through a sophisticated network of activating and inhibitory receptors. As effectors of cancer …

Adoptive transfer of antitumor lymphocytes has gained intense interest in the field of cancer
therapeutics over the past two decades. Human natural killer (NK) cells are a promising …

Natural killer (NK) cells play an essential role in the fight against tumor development. Over
the last years, the progress made in the NK-cell biology field and in deciphering how NK-cell …