Despite recent advances in cancer treatment over the past 30 years, therapeutic options
remain limited and do not always offer a cure for malignancy. Given that tumor-associated …

Adoptive cell transfer (ACT) of antigen-specific CD8+ cytotoxic T lymphocytes (CTLs) is a
promising treatment for a variety of malignancies 1. CTLs can recognize malignant cells by …

Abstract Purpose of Review In the rapidly developing field of adoptive cell immunotherapy,
there is urgent need for discoveries that would improve outcomes, extend the applicability …

Simple Summary Induced pluripotent stem cells (iPSCs) that can be genetically engineered
and differentiated into different types of immune cells, providing an unlimited resource for …

Simple Summary Adoptive cell therapy (ACT) is an innovative approach to combat cancer
and infectious diseases using specialised immune cells, such as chimeric antigen receptor T …

Progress in adoptive T-cell therapy for cancer and infectious diseases, is hampered by the
lack of readily available, antigen-specific, human T lymphocytes. Pluripotent stem cells could …

Adoptive cell therapy (ACT) using chimeric antigen receptor (CAR) T cells holds impressive
clinical outcomes especially in patients who are refractory to other kinds of therapy …

T lymphocytes are critical mediators of the adaptive immune system and they can be
harnessed as therapeutic agents against pathogens and in cancer immunotherapy. T cells …

In recent years, great strides have been made toward the development of immune cell‐
based therapies in the treatment of refractory malignancies. Primary T cells and NK cells …

Tumor-infiltrating lymphocytes (TIL) that can recognize and kill tumor cells have curative
potential in subsets of patients treated with adoptive cell transfer (ACT). However, lack of TIL …