21 optimizes the FL-driven development of Irf8-dependent cDC1 (cDC1Notch) by inducing
Notch. The resulting cDC1Notch present with a CD8α+ Dec205+ CD103+ phenotype …

CD4+ T follicular helper (TFH) cells support germinal center (GC) reactions promoting
humoral immunity. Dendritic cell (DC) diversification into genetically distinct subsets allows …

Conventional dendritic cells (cDCs) consist of two major functionally and phenotypically
distinct subsets, cDC1 and cDC2, whose development is dependent on distinct sets of …

Members of the Interferon Regulatory Factor (IRF) family of transcription factors play an
essential role in the development and function of the immune system. Here we investigated …

Conventional dendritic cells (cDC) consist of two functionally and phenotypically distinct
subsets, cDC1 and cDC2, whose development is dependent on distinct sets of transcription …

The development of two conventional dendritic cells (DC) subsets (cDC1 and cDC2) and the
plasmacytoid DC (pDC) in vivo and in cultures of bone marrow (BM) cells is mediated by the …

Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their
heterogeneity and functional specialization is still ill-defined. Here we show that deletion of …

Intrathymic T cell development is predicated on the Notch1 ligand Delta-like (Dll) 4.
However, both Dll4 and Dll1 can support T cell development in vitro. Endocytosis of Dll1 is …

Abstract Characterization of the functional effects of cDC2s in vivo requires model systems in
which cDC2s are depleted. Previous literature has reported a loss of cDC2s in mice lacking …

Interferon regulatory factor 8 (IRF8) has long been associated with conventional dendritic
cell type I (cDC1) development. In a recent study, Lança et al. demonstrate that IRF8 is also …