Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as
hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha‐lipoic acid (α …

Abstract Aims/hypothesis Sirtuin 1 (SIRT1) is a longevity-associated protein, which regulates
energy metabolism and lifespan in response to nutrient deprivation. It has been proposed to …

Abstract (R)‐α‐lipoic acid (ALA), an essential cofactor in mitochondrial respiration and a
potential antioxidant, possesses a wide array of metabolic benefits including anti‐obesity …

Reducing the prevalence of obesity and obesity-related metabolic disturbances is the
foremost priority of global health care initiatives. Sustained lifestyle modifications to diet and …

In animal experiments, the potent antioxidant and free radical scavenger α-lipoic acid has
been shown to cause weight loss, ameliorate insulin resistance and atherogenic …

Recent data have revealed that oxidative products and inflammatory mediators are
increased in the insulin‐resistant states of obesity and type 2 diabetes mellitus (T2DM) …

Objective α‐Lipoic acid (α‐LA) is a natural occurring antioxidant with beneficial effects on
obesity. The aim of this study was to investigate the putative effects of α‐LA on triglyceride …

Aim: To investigate whether alpha-lipoic acid (ALA) could attenuate the insulin resistance
and metabolic disorders in high fat diet-fed mice. Methods: Male mice were fed a high fat …

Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …

Skeletal muscle mitochondrial dysfunction is associated with aging and diabetes, which
decreases respiratory capacity and increases reactive oxygen species. Lipoic acid (LA) …