Hemorrhagic strokes such as intracerebral hemorrhage (ICH) and subarachnoid
hemorrhage (SAH) are common diseases, but their effective treatments are limited. As a …

The hemolysis of red blood cells after intracerebral hemorrhage (ICH) releases hemoglobin
degradation products and iron, which precipitate a cascade of events, including free …

J. Neurochem.(2012) 121, 785–792. Abstract Delayed cerebral ischemia resulting from
extracellular hemoglobin is an important determinant of outcome in subarachnoid …

After a cerebral hemorrhage (intracerebral, subarachnoid, and intraventricular),
extravasated blood contributes to both initial brain injury, via physical disruption and mass …

Stroke constitutes the second highest cause of morbidity and mortality worldwide while also
impacting the world economy, triggering substantial financial burden in national health …

Haemoglobin is released into the CNS during the breakdown of red blood cells after
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …

Hemorrhagic stroke is a disease with high incidence and mortality rates. In addition to the
mass lesions that result from hemorrhagic stroke, substances such as the blood-derived …

Intracerebral hemorrhage (ICH) is a common cerebrovascular disorder with high morbidity
and mortality. Secondary brain injury after ICH, which is initiated by multiple hemolytic …

Following intracerebral hemorrhage (ICH), clot-derived factors cause secondary brain
damage. In particular, hemoglobin released during erythrolysis has been the focus of a large …

Our recent study has demonstrated that hemoglobin (Hb) is present in cerebral neurons, and
neuronal Hb is inducible after cerebral ischemia. In the present study, we examined the …