Dithiolethiones, a novel class of adenosine monophosphate‐activated protein kinase
(AMPK) activators, prevent insulin resistance through AMPK‐dependent p70 ribosomal S6 …

Liver X receptor-α (LXRα), a member of the nuclear receptor superfamily of ligand-activated
transcription factors, regulates de novo fatty acid synthesis that leads to stimulate hepatic …

Collaborative regulation of liver X receptor (LXR) and sterol regulatory element binding
protein (SREBP)-1 are main determinants in hepatic steatosis, as shown in both animal …

PXR was isolated as a “xenobiotic receptor” that regulates drug-metabolizing enzymes and
transporters, whereas LXR is known to promote hepatic lipogenesis by activating the …

Nonalcoholic fatty liver disease (NAFLD) is a very common liver disease, and its incidence
has significantly increased worldwide. The liver X receptor α (LXRα) is a multifunctional …

Sterol regulatory element-binding protein-1c (SREBP-1c) increases lipogenesis at the
transcriptional level, and its expression is upregulated by liver X receptor α (LXRα). The …

Non-alcoholic fatty liver disease is associated with inhibited AMP-activated kinase (AMPK)
and activation of sterol regulatory element binding protein 1 (SREBP-1). AMPK …

Licochalcone (LC), a major phenolic retrochalcone from licorice, has anti-inflammatory
activity. This study investigated the effects of licochalcone A (LCA) and licochalcone E (LCE) …

Hepatic steatosis, a hepatic component of metabolic syndrome, is common and may
progress to steatohepatitis and cirrhosis. The liver X receptor-α (LXRα)-sterol regulatory …

Comprehensive studies support the notion that oltipraz [4-methyl-5-(2-pyrazynyl)-1, 2-
dithiole-3-thione] and its congeners exert cancer chemopreventive effects by the prevention …