Paradoxical instability–activity relationship defines a novel regulatory pathway for retinoblastoma proteins
The Retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins
play central roles in cell cycle control and development, and the regulatory networks …
play central roles in cell cycle control and development, and the regulatory networks …
[HTML][HTML] Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function
The retinoblastoma (RB) tumor suppressor family functions as a regulatory node governing
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …
[HTML][HTML] Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein
The retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events
including cell cycle, senescence, and differentiation. The activity and stability of these …
including cell cycle, senescence, and differentiation. The activity and stability of these …
[HTML][HTML] The evolutionarily conserved C-terminal domains in the mammalian retinoblastoma tumor suppressor family serve as dual regulators of protein stability and …
S Sengupta, R Lingnurkar, TS Carey… - Journal of Biological …, 2015 - ASBMB
The retinoblastoma (RB) tumor suppressor and related family of proteins play critical roles in
development through their regulation of genes involved in cell fate. Multiple regulatory …
development through their regulation of genes involved in cell fate. Multiple regulatory …
Diversification of retinoblastoma protein function associated with cis and trans adaptations
Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in
cell cycle control, among other functions. Although most metazoan genomes encode a …
cell cycle control, among other functions. Although most metazoan genomes encode a …
Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation
JS Elenbaas, R Mouawad, RW Henry, DN Arnosti… - Cell cycle, 2015 - Taylor & Francis
The RB tumor suppressor, a regulator of the cell cycle, apoptosis, senescence, and
differentiation, is frequently mutated in human cancers. We recently described an …
differentiation, is frequently mutated in human cancers. We recently described an …
Distinct developmental expression of Drosophila retinoblastoma factors
SA Keller, Z Ullah, MS Buckley, RW Henry… - Gene expression …, 2005 - Elsevier
Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
[HTML][HTML] The retinoblastoma (RB) tumor suppressor: pushing back against genome instability on multiple fronts
R Vélez-Cruz, DG Johnson - International journal of molecular sciences, 2017 - mdpi.com
The retinoblastoma (RB) tumor suppressor is known as a master regulator of the cell cycle.
RB is mutated or functionally inactivated in the majority of human cancers. This …
RB is mutated or functionally inactivated in the majority of human cancers. This …
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
WR Sellers, BG Novitch, S Miyake, A Heith… - Genes & …, 1998 - genesdev.cshlp.org
The retinoblastoma tumor suppressor protein (pRB) can inhibit cell cycle progression and
promote differentiation. pRB interacts with a variety of transcription factors, including …
promote differentiation. pRB interacts with a variety of transcription factors, including …
Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation
SP Angus, DA Solomon, L Kuschel… - … and cellular biology, 2003 - Taylor & Francis
The retinoblastoma tumor suppressor, RB, assembles multiprotein complexes to mediate
cell cycle inhibition. Although many RB binding partners have been suggested to underlie …
cell cycle inhibition. Although many RB binding partners have been suggested to underlie …