The complex pathogenesis of Alzheimer's disease (AD) has become a major obstacle in its
treatment. An effective approach is to develop multifunctional agents that simultaneously …

In order to produce an effective and multi-targeted clinical drug that could prevent
progressive neurodegeneration, a series of diosgenin carbamate derivatives were …

Alzheimer's disease is a progressive neurodegenerative disease, and its incidence is
expected to increase as the global population ages. Recent studies provide increasing …

The multifaceted nature of Alzheimer's disease (AD) demands treatment with multitarget-
directed ligands (MTDLs) to confront the key pathological aberrations. A novel series of …

Alzheimer's disease (AD, also known as dementia) has become a serious global health
problem along with population aging, and neuroinflammation is the underlying cause of …

Based on multitarget-directed ligands approach, through two rounds of screening, a series
of 2-aminoalkyl-6-(2-hydroxyphenyl) pyridazin-3 (2H)-one derivatives were designed …

Abstract A series of novel 2-(4-(4-substituted piperazin-1-yl) benzylidene)-1H-indene-1, 3
(2H)-diones were designed, synthesized and appraised as multifunctional anti-Alzheimer …

A novel series of benzylideneindanone derivatives were designed, synthesized, and
evaluated as multitarget-directed ligands against Alzheimer's disease. The in vitro studies …

A novel series of donepezil based multi-functional agents “(E)-5, 6-dimethoxy-2-(4-(4-
substituted piperazin-1-yl) benzylidene)-2, 3-dihydro-1H-inden-1-ones” have been designed …

The most frequent type of age-related dementia is Alzheimer's disease. To discover novel
therapeutic agents for Alzheimer's disease, a series of substituted pyrimidine derivatives …