Immunological responses to semen in the female genital tract

HJ Schuberth, U Taylor, H Zerbe, D Waberski, R Hunter… - Theriogenology, 2008 - Elsevier
When spermatozoa, seminal plasma and semen extender reach the uterus and interact with
local leukocytes and endometrial cells, several immune mechanisms are initiated which …

Post‐mating inflammatory responses of the uterus

T Katila - Reproduction in domestic animals, 2012 - Wiley Online Library
Contents This review attempts to summarize the current knowledge on uterine inflammatory
response after mating in horses, pigs and cattle. Post‐mating endometritis has been …

Seminal fluid and immune adaptation for pregnancy–comparative biology in mammalian species

JE Schjenken, SA Robertson - Reproduction in Domestic …, 2014 - Wiley Online Library
Contents Seminal fluid delivered to the female reproductive tract at coitus not only promotes
the survival and fertilizing capacity of spermatozoa, but also contains potent signalling …

Sperm interaction with the uterine innate immune system: toll-like receptor 2 (TLR2) is a main sensor in cattle

I Akthar, MA Marey, Y Kim, M Shimada… - Reproduction …, 2021 - CSIRO Publishing
During the passage through the female reproductive tract, sperm interact with various
compartments and their immune systems. The immune system that protects the female …

Seminal 'priming'for protection from pre-eclampsia—a unifying hypothesis

SA Robertson, JJ Bromfield, KP Tremellen - Journal of reproductive …, 2003 - Elsevier
Conventional belief holds that an immune response to ejaculate antigens should interfere
with fertilisation and establishment of pregnancy. However, emerging evidence now …

The seminal plasma of the boar is rich in cytokines, with significant individual and intra‐ejaculate variation

I Barranco, M Rubér, C Perez‐Patiño… - American Journal of …, 2015 - Wiley Online Library
Problem The boar, as human, sequentially ejaculates sperm‐rich and sperm‐poor fractions.
Seminal plasma (SP) spermadhesins (PSP‐I/PSP‐II) induce a primary endometrial …

Immune regulatory molecules as modifiers of semen and fertility: A review

SS Archana, S Selvaraju, BK Binsila… - Molecular …, 2019 - Wiley Online Library
Declining fertility rates in both human and animals is a cause for concern. While many of the
infertility cases are due to known causes, idiopathic infertility is reported in 30% of the …

Semen activates the female immune response during early pregnancy in mice

M Johansson, JJ Bromfield, MJ Jasper… - …, 2004 - Wiley Online Library
Insemination elicits inflammatory changes in female reproductive tissues, but whether this
results in immunological priming to paternal antigens or influences pregnancy outcome is …

Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig

S O'leary, MJ Jasper, GM Warnes… - …, 2004 - rep.bioscientifica.com
In pigs, uterine exposure to the constituents of semen is known to increase litter size but the
underlying physiological mechanisms remain undefined. Studies in rodents and humans …

The role of semen in induction of maternal immune tolerance to pregnancy

SA Robertson, DJ Sharkey - Seminars in immunology, 2001 - Elsevier
Successful pregnancy requires a state of maternal immune 'tolerance'to accommodate
antigens expressed by the conceptus. Implantation failure and placental pathologies largely …