Induced pluripotent stem cell (iPSC) therapy brings great hope to the treatment of
myocardial injuries, while extracellular vesicles may be one of the main mechanisms of its …

Rationale: Extracellular vesicles (EVs) are tiny membrane-enclosed droplets released by
cells through membrane budding or exocytosis. The myocardial reparative abilities of EVs …

EVs isolation using serum-free conditions may have potential future clinical applications to
accelerate cardiac repair. iPSCs are indeed able to differentiate into cells of diverse …

Cardiovascular disease (CVD) is the leading cause of death in modern society. The adult
heart innately lacks the capacity to repair and regenerate the damaged myocardium from …

Background Stem cell–secreted extracellular vesicles (EVs) play essential roles in
intercellular communication and restore cardiac function in animal models of ischemic heart …

Background/objectives Induced pluripotent stem cells (iPS) exhibit enhanced survival and
proliferation in ischemic tissues. However, the therapeutic application of iPS cells is limited …

Although cell survival post-transplantation is very low, emerging evidence using stem cell
therapy for myocardial repair points toward a primary role of paracrine signaling …

Myocardial infarction (MI) is a common cardiovascular disease caused by permanent loss of
cardiomyocytes and the formation of scar tissue due to myocardial ischemia. Mammalian …

Transplanted induced pluripotent stem cells (IPSC) and embryonic stem cells (ESC) exhibit
enhanced survival in ischemic tissues and promote survival of neighboring cells via …

Human pluripotent stem cells (hPSCs)-derived cardiovascular progenitor cells (CVPCs) are
a promising source for myocardial repair, while the mechanisms remain largely unknown …