Evaluation of antileishmanial potential of computationally screened compounds targeting DEAD-box RNA helicase of Leishmania donovani

SC Pandey, A Jha, A Kumar, M Samant - International journal of biological …, 2019 - Elsevier
Visceral leishmaniasis (VL) is one of the most devastating diseases of the tropical region
caused by protozoan parasite Leishmania donovani. So far, there is no effective drug and …

Discovery of novel anti-leishmanial agents targeting LdLip3 lipase

S Parameswaran, P Saudagar, VK Dubey… - Journal of Molecular …, 2014 - Elsevier
Leishmaniasis is a neglected tropical disease, caused by several species of Leishmania.
Being an opportunistic lipid-scavenging pathogen, Leishmania relies extensively on lipid …

Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery

CR dos Santos Vasconcelos, AM Rezende - Frontiers in Chemistry, 2021 - frontiersin.org
Leishmaniasis is a group of neglected infectious diseases, with approximately 1. 3 million
new cases each year, for which the available therapies have serious limitations. Therefore, it …

Drug repurposing based novel anti-leishmanial drug screening using in-silico and in-vitro approaches

P Rai, H Arya, S Saha, D Kumar… - Journal of Biomolecular …, 2022 - Taylor & Francis
Visceral leishmaniasis is a neglected tropical disease and is mainly caused by L. donovani
in the Indian subcontinent. The mitochondria genome replication in Leishmania spp. is …

Some scaffolds as anti-leishmanial agents: A review

T Mahender, W Pankaj, SP Kumar… - Mini reviews in …, 2022 - ingentaconnect.com
Leishmaniasis is a parasitic infectious neglected tropical disease transmitted to humans by
the parasites of Leishmania species. Mainly, three types of leishmaniases are usually …

Discovery and validation of Lmj_04_BRCT domain, a novel therapeutic target: identification of candidate drugs for leishmaniasis

J Peña-Guerrero, C Fernández-Rubio… - International Journal of …, 2021 - mdpi.com
Since many of the currently available antileishmanial treatments exhibit toxicity, low
effectiveness, and resistance, search and validation of new therapeutic targets allowing the …

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

E Harigua-Souiai, YZ Abdelkrim… - PLoS Neglected …, 2018 - journals.plos.org
Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on
public health. The identification of novel drugs and targets constitutes a research priority. For …

Biophysical and modeling-based approach for the identification of inhibitors against DOHH from Leishmania donovani

M Katiki, M Sharma, N Neetu… - Briefings in Functional …, 2023 - academic.oup.com
The amino acid hypusine (Nε-4-amino-2-hydroxybutyl (lysine)) occurs only in isoforms of
eukaryotic translation factor 5A (eIF5A) and has a role in initiating protein translation …

Exploring actinomycetes natural products to identify potential multi-target inhibitors against Leishmania donovani

S Singh, VK Prajapati - 3 Biotech, 2022 - Springer
Visceral leishmaniasis (VL) is a neglected tropical disease that mainly affects the poor
population of the Indian, African, and South American subcontinent. The increasing …

Molecular modeling and virtual screening approach to discover potential antileishmanial inhibitors against ornithine decarboxylase

R Kumar Pandey, P Prajapati, S Goyal… - … chemistry & high …, 2016 - ingentaconnect.com
Background: Visceral leishmaniasis (VL) is a tropical neglected disease, which encounters
poorest of poor people living in Asia, Africa and Latin America; causing the mortality of more …