Evaluation of antileishmanial potential of computationally screened compounds targeting DEAD-box RNA helicase of Leishmania donovani
Visceral leishmaniasis (VL) is one of the most devastating diseases of the tropical region
caused by protozoan parasite Leishmania donovani. So far, there is no effective drug and …
caused by protozoan parasite Leishmania donovani. So far, there is no effective drug and …
Discovery of novel anti-leishmanial agents targeting LdLip3 lipase
Leishmaniasis is a neglected tropical disease, caused by several species of Leishmania.
Being an opportunistic lipid-scavenging pathogen, Leishmania relies extensively on lipid …
Being an opportunistic lipid-scavenging pathogen, Leishmania relies extensively on lipid …
Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery
CR dos Santos Vasconcelos, AM Rezende - Frontiers in Chemistry, 2021 - frontiersin.org
Leishmaniasis is a group of neglected infectious diseases, with approximately 1. 3 million
new cases each year, for which the available therapies have serious limitations. Therefore, it …
new cases each year, for which the available therapies have serious limitations. Therefore, it …
Drug repurposing based novel anti-leishmanial drug screening using in-silico and in-vitro approaches
Visceral leishmaniasis is a neglected tropical disease and is mainly caused by L. donovani
in the Indian subcontinent. The mitochondria genome replication in Leishmania spp. is …
in the Indian subcontinent. The mitochondria genome replication in Leishmania spp. is …
Some scaffolds as anti-leishmanial agents: A review
T Mahender, W Pankaj, SP Kumar… - Mini reviews in …, 2022 - ingentaconnect.com
Leishmaniasis is a parasitic infectious neglected tropical disease transmitted to humans by
the parasites of Leishmania species. Mainly, three types of leishmaniases are usually …
the parasites of Leishmania species. Mainly, three types of leishmaniases are usually …
Discovery and validation of Lmj_04_BRCT domain, a novel therapeutic target: identification of candidate drugs for leishmaniasis
J Peña-Guerrero, C Fernández-Rubio… - International Journal of …, 2021 - mdpi.com
Since many of the currently available antileishmanial treatments exhibit toxicity, low
effectiveness, and resistance, search and validation of new therapeutic targets allowing the …
effectiveness, and resistance, search and validation of new therapeutic targets allowing the …
Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A
E Harigua-Souiai, YZ Abdelkrim… - PLoS Neglected …, 2018 - journals.plos.org
Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on
public health. The identification of novel drugs and targets constitutes a research priority. For …
public health. The identification of novel drugs and targets constitutes a research priority. For …
Biophysical and modeling-based approach for the identification of inhibitors against DOHH from Leishmania donovani
The amino acid hypusine (Nε-4-amino-2-hydroxybutyl (lysine)) occurs only in isoforms of
eukaryotic translation factor 5A (eIF5A) and has a role in initiating protein translation …
eukaryotic translation factor 5A (eIF5A) and has a role in initiating protein translation …
Exploring actinomycetes natural products to identify potential multi-target inhibitors against Leishmania donovani
S Singh, VK Prajapati - 3 Biotech, 2022 - Springer
Visceral leishmaniasis (VL) is a neglected tropical disease that mainly affects the poor
population of the Indian, African, and South American subcontinent. The increasing …
population of the Indian, African, and South American subcontinent. The increasing …
Molecular modeling and virtual screening approach to discover potential antileishmanial inhibitors against ornithine decarboxylase
R Kumar Pandey, P Prajapati, S Goyal… - … chemistry & high …, 2016 - ingentaconnect.com
Background: Visceral leishmaniasis (VL) is a tropical neglected disease, which encounters
poorest of poor people living in Asia, Africa and Latin America; causing the mortality of more …
poorest of poor people living in Asia, Africa and Latin America; causing the mortality of more …