Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly
in older patients. Several immunomodulating therapies seem less beneficial in these …

Age is a risk factor for coronavirus disease 2019 (COVID-19)-associated morbidity and
mortality in humans; hence, in this study, we compared the course of severe acute …

Cellular senescence permanently arrests the replication of various cell types and contributes
to age-associated diseases. In particular, cellular senescence may enhance chronic lung …

With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

The SARS-CoV-2 pandemic has almost 56 million confirmed cases resulting in over 1.3
million deaths as of November 2020. This infection has proved more deadly to older adults …

The COVID-19 pandemic serves as a potent reminder that older people are at very high risk
of adverse outcomes from infectious disease because of comorbidities associated with …

The recently identified SARS-CoV-2 betacoronavirus responsible for the COVID-19
pandemic has uncovered the age-associated vulnerability in the burden of disease and put …

The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …

The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …