[HTML][HTML] Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

A Ciabattini, P Garagnani, F Santoro… - Seminars in …, 2020 - Springer
The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools.
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …

COVID‐19 is an emergent disease of aging

D Santesmasses, JP Castro, AA Zenin… - Aging cell, 2020 - Wiley Online Library
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …

[HTML][HTML] The COVID-19 pandemic: does our early life environment, life trajectory and socioeconomic status determine disease susceptibility and severity?

C Holuka, MP Merz, SB Fernandes… - International journal of …, 2020 - mdpi.com
A poor socioeconomic environment and social adversity are fundamental determinants of
human life span, well-being and health. Previous influenza pandemics showed that …

[HTML][HTML] Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition

L Bencivenga, G Rengo, G Varricchi - Geroscience, 2020 - Springer
The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the
majority of deaths are occurring in older people. A partial description of the magnitude of the …

[PDF][PDF] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity

CR Moderbacher, SI Ramirez, JM Dan, A Grifoni… - Cell, 2020 - cell.com
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …

[HTML][HTML] Geriatric population during the COVID-19 pandemic: problems, considerations, exigencies, and beyond

K Dhama, SK Patel, R Kumar, J Rana… - Frontiers in public …, 2020 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic wreaked havoc worldwide, with more
than 20 million confirmed cases and nearly 0. 75 million deaths as of 10th August 2020 …

COVID-19 in the elderly people and advances in vaccination approaches

K Dhama, SK Patel, S Natesan, KS Vora… - Human vaccines & …, 2020 - Taylor & Francis
The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of …

[HTML][HTML] SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes

J Nikolich-Zugich, KS Knox, CT Rios, B Natt… - Geroscience, 2020 - Springer
Abstract SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …

[HTML][HTML] Covid-19 pandemic: maximizing future vaccination treatments considering aging and frailty

S Palermo - Frontiers in medicine, 2020 - frontiersin.org
The COVID-19 pandemic is proving to be a multiplier of inequalities. Especially toward the
elderly population. A voiceless scream that comes from geriatrics, nursing homes, hospices …

[HTML][HTML] COVID-19, virology and geroscience: a perspective

C Vellas, P Delobel, PDS Barreto, J Izopet - The journal of nutrition, health …, 2020 - Elsevier
A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019.
The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease …