Constitutive and inducible expression of the gene encoding the modulator subunit of human
glutamate-cysteine ligase (GCLM) is regulated by either of two regions of the promoter; an …

Glutamate–cysteine ligase is a heterodimer comprising a modifier (GCLM) and a catalytic
(GCLC) subunit. In mouse Hepa-1c1c7 hepatoma cell cultures, we found that tert …

Glutathione (GSH) is the primary nonprotein thiol in the cell. It has many important roles in
cell function, including regulating redox-dependent signal transduction pathways. The …

Glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione synthesis, is made
up of two subunits, a catalytic (heavy) subunit (GCLC) and a modifier (light) subunit (GCLM) …

Despite it being a quintessential Phase II detoxification gene, the transcriptional regulation
of the rat γ-glutamate cysteine ligase catalytic subunit (GCLC) is controversial. Computer …

Glutamate cysteine ligase (GCL) catalyzes the rate-limiting step in the formation of the
cellular antioxidant glutathione (GSH). The GCL holoenzyme consists of two separately …

Glutamate cysteine ligase (GCL), composed of a catalytic (GCLC) and modulatory (GCLM)
subunit, catalyzes the first step of glutathione (GSH) biosynthesis. Using 4-hydroxy-2 …

Background—Human glutamate-cysteine ligase (GCL) is a rate-limiting enzyme for the
synthesis of glutathione that plays a crucial role in antioxidant defense mechanisms in most …

The antioxidant response element (ARE) is an essential component of upstream regulatory
sequences present on genes for most phase II detoxification enzymes, including the …

Mutation analysis of putative regulatory elements located in the 5´-flanking region of the
gene encoding the regulatory subunit of γ-glutamylcysteine synthetase (GLCLR) revealed …