Temporomandibular joint inflammation potentiates the excitability of trigeminal root ganglion neurons innervating the facial skin in rats

M Takeda, T Tanimoto, M Ikeda… - Journal of …, 2005 - journals.physiology.org
The aim of this study was to test the hypothesis that temporomandibular joint (TMJ)
inflammation alters the excitability of trigeminal root ganglion (TRG) neurons innervating the …

Activation of NK1 receptor of trigeminal root ganglion via substance P paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint …

M Takeda, T Tanimoto, M Nasu, M Ikeda, J Kadoi… - Pain, 2005 - journals.lww.com
The aim of this study was to investigate whether under in vivo conditions,
temporomandibular joint (TMJ) inflammation alters the excitability of Aβ-trigeminal root …

Enhanced excitability of rat trigeminal root ganglion neurons via decrease in A-type potassium currents following temporomandibular joint inflammation

M Takeda, T Tanimoto, M Ikeda, M Nasu, J Kadoi… - Neuroscience, 2006 - Elsevier
The aim of the present study was to investigate the effect of temporomandibular joint
inflammation on the excitability of trigeminal root ganglion neurons innervating the …

Suppression of neurokinin‐1 receptor in trigeminal ganglia attenuates central sensitization following inflammation

M Takeda, M Takahashi… - Journal of the Peripheral …, 2012 - Wiley Online Library
This study examined whether local application of a neurokinin‐1 (NK1) receptor antagonist
into the trigeminal ganglia (TRGs) modulates hyperexcitability of trigeminal spinal nucleus …

Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats

Y Yamazaki, K Ren, M Shimada, K Iwata - Experimental neurology, 2008 - Elsevier
To evaluate the involvement of paratrigeminal nucleus (Pa5) nociceptive neurons in
temporomandibular joint (TMJ) inflammation-induced pain and its autonomic correlates, we …

[HTML][HTML] CENTRAL ROLE OF PROTEIN KINASE A IN PROMOTING TRIGEMINAL NOCICEPTION IN AN IN VIVO MODEL OF TEMPOROMANDIBULAR JOINT …

LK Koop, JL Hawkins, LE Cornelison… - … of oral & facial pain and …, 2017 - ncbi.nlm.nih.gov
Aims To investigate cellular changes in the spinal trigeminal nucleus (STN) and trigeminal
ganglion associated with trigeminal nociception mediated by inflammation in the …

Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation implications for persistent temporomandibular pain

H Imbe, K Iwata, QQ Zhou, S Zou, R Dubner… - Cells Tissues …, 2001 - karger.com
A rat model has been developed to characterize the responses of brainstem trigeminal
neurons to orofacial deep and cutaneous tissue inflammation and hyperalgesia. Complete …

Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats

M Takeda, T Tanimoto, M Nasu, S Matsumoto - European journal of pain, 2008 - Elsevier
Voltage-gated K+ (Kv) channels are one of the important physiological regulators of the
membrane potentials in excitable cells, including sensory ganglion neurons. The aim of the …

[PDF][PDF] Neurophysiology of orofacial pain

K Iwata, M Takeda, SB Oh… - Contemporary oral …, 2017 - researchgate.net
It is well known that unmyelinated C-fibers and small-diameter Aδ-fibers innervate the
orofacial skin, mucous membrane, orofacial muscles, teeth, tongue, and temporomandibular …

Peripheral and central mechanisms of persistent orofacial pain

M Shinoda, A Kubo, Y Hayashi, K Iwata - Frontiers in Neuroscience, 2019 - frontiersin.org
Neuroplastic changes in the neuronal networks involving the trigeminal ganglion (TG),
trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1/C2) are …