Privileged structures are conductive to discover novel bioactive substances because they
can bind to multiple targets with high affinity. Quinones are considered to be a privileged …

Quinoline-based small molecules have been explored and being developed as anti-
inflammatory agents targeting several pharmacological targets namely Phosphodiesterase 4 …

Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of
biological activities, including antimicrobial, anticancer, and antifungal effects. The chemistry …

Antibiotics are becoming gradually ineffective due to drug resistance, leading to greater
difficulty in the treatment of infectious diseases. Therefore, the development of new chemical …

Background & Objective: The emergence of multidrug-resistant virus, bacteria and fungi has
created an urgent need for the development of novel antibiotic drugs from natural products …

In an attempt for development of new antimicrobial agents, three series of quinoline
derivatives bearing pyrazole moiety have been synthesized. The first series was synthesized …

Introduction: The concept of privileged structures is well known and is often used in the
process of drug design and development. Although its assumptions are not clear, its overall …

The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

The emergence of drug resistance and low specificity with side effects are the significant
challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this …