Stromal cells in the vicinity of tumour cells are not an inert component of an organ. Cancer
cells induce the fibroblasts of the surrounding connective tissue to develop into carcinoma …

In the past century, gradual but sustained advances in our understanding of the molecular
mechanisms involved in the growth and invasive properties of cancer cells have led to better …

Solid tumours are multi-cellular tissues comprised of tumour cells and stromal cells,
including fibroblasts, endothelial cells and inflammatory cells. When a cancer cell …

The mechanisms involved in the tumor-stroma interaction during carcinoma progression are
an area of intensive investigation. Cancer cells produce a range of growth factors and …

The understanding of how normal cells transform into tumor cells and progress to invasive
cancer and metastases continues to evolve. The tumor mass is comprised of a …

While research previously focused extensively on the tumor cells, over the last two decades,
the tumor microenvironment (TME) has received increasing attention with a particular …

The basement membrane, immune cells, capillaries, fibroblasts and extracellular matrix
(ECM) constitute the tumour stroma, commonly referred to as the 'reactive stroma'. The …

Tumor‐associated stromal cells are dynamic characters that endorse the carcinogenic
process in a multitude of ways. The tumor microenvironment plays a crucial role throughout …

Tumor tissue is composed of both cancer cells and stromal cells recruited from normal
tissue. These cells include fibroblastic cells, endothelial cells, and cells of hematopoietic …

The majority of studies of neoplastic transformation have focused attention on events that
occur within transformed cells. These cell autonomous events result in the disruption of …