RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1

M Chibi, M Meyer, A Skepu, DJG Rees… - Journal of molecular …, 2008 - Elsevier
RBBP6 (retinoblastoma binding protein 6) is a 250-kDa multifunctional protein that interacts
with both p53 and pRb and has been implicated in mRNA processing. It has also been …

[HTML][HTML] YB-1 is a transcription/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression

J Wu, AL Stratford, A Astanehe… - Translational …, 2007 - ncbi.nlm.nih.gov
Abstract The Y-box Binding Protein-1 (YB-1) is a highly conserved oncogenic transcription/
translation factor that is expressed in cancers affecting adults and children. It is now believed …

YB-1: oncoprotein, prognostic marker and therapeutic target?

A Lasham, CG Print, AG Woolley, SE Dunn… - Biochemical …, 2013 - portlandpress.com
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-box

MA Kappo, AB Eiso, F Hassem, RA Atkinson… - Journal of Biological …, 2012 - ASBMB
Retinoblastoma-binding protein-6 (RBBP6) plays a facilitating role, through its RING finger-
like domain, in the ubiquitination of p53 by Hdm2 that is suggestive of E4-like activity …

YB-1 as a potential target in cancer therapy

H Lage, P Surowiak, PS Holm - Der Pathologe, 2008 - Springer
The 42-kDa multifunctional cellular protein Y-box protein 1 (YB-1) is expressed in various
cancers. It is localized in the cytoplasm as well as in the nucleus. In particular, YB-1 is …

Y-box binding protein 1–a prognostic marker and target in tumour therapy

C Kosnopfel, T Sinnberg, B Schittek - European journal of cell biology, 2014 - Elsevier
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular
processes including both transcriptional and translational regulation of target gene …

YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

A Alkrekshi, W Wang, PS Rana, V Markovic… - Cellular signalling, 2021 - Elsevier
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …

YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation

T Uchiumi, A Fotovati, T Sasaguri, K Shibahara… - Journal of Biological …, 2006 - ASBMB
The eukaryotic Y-box-binding protein-1 (YB-1) is involved in the transcriptional and
translational control of many biological processes, including cell proliferation. In clinical …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and
translation factor during expression of several proteins. It is a vital oncoprotein that regulates …