Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis
YM Khaw, A Tierney, C Cunningham… - Proceedings of the …, 2021 - National Acad Sciences
Multiple sclerosis (MS) is a chronic neurological disease of the central nervous system
driven by peripheral immune cell infiltration and glial activation. The pathological hallmark of …
driven by peripheral immune cell infiltration and glial activation. The pathological hallmark of …
AB cell–driven EAE mouse model reveals the impact of B cell–derived cytokines on CNS autoimmunity
AS Thomann, CA McQuade… - Proceedings of the …, 2023 - National Acad Sciences
In multiple sclerosis (MS), pathogenic T cell responses are known to be important drivers of
autoimmune inflammation. However, increasing evidence suggests an additional role for B …
autoimmune inflammation. However, increasing evidence suggests an additional role for B …
[HTML][HTML] Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model
E Mills Ko, JH Ma, F Guo, L Miers, E Lee… - Journal of …, 2014 - Springer
Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation,
demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells …
demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells …
[HTML][HTML] Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis
KD DiSano, MR Linzey, DB Royce, AR Pachner… - Journal of …, 2019 - Springer
Background The mechanisms driving multiple sclerosis (MS), the most common cause of
non-traumatic disability in young adults, remain unknown despite extensive research …
non-traumatic disability in young adults, remain unknown despite extensive research …
[PDF][PDF] Bone marrow hematopoiesis drives multiple sclerosis progression
K Shi, H Li, T Chang, W He, Y Kong, C Qi, R Li… - Cell, 2022 - cell.com
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous
system (CNS). Bone marrow hematopoietic stem and progenitor cells (HSPCs) rapidly …
system (CNS). Bone marrow hematopoietic stem and progenitor cells (HSPCs) rapidly …
Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation
Multiple sclerosis (MS) is characterized by pathological inflammation that results from the
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …
Infiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …
[HTML][HTML] Role of T cell—glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms
ES Huseby, D Kamimura, Y Arima… - Frontiers in cellular …, 2015 - frontiersin.org
Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System (CNS)
that causes the demyelination of nerve cells and destroys oligodendrocytes, neurons and …
that causes the demyelination of nerve cells and destroys oligodendrocytes, neurons and …
[HTML][HTML] Myelin-specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity
CA Wagner, PJ Roqué, TR Mileur… - The Journal of …, 2020 - Am Soc Clin Investig
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the CNS. Although
CD4+ T cells are implicated in MS pathogenesis and have been the main focus of MS …
CD4+ T cells are implicated in MS pathogenesis and have been the main focus of MS …
IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells
A Paré, B Mailhot, SA Lévesque… - Proceedings of the …, 2018 - National Acad Sciences
Molecular interventions that limit pathogenic CNS inflammation are used to treat
autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β–knockout mice …
autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β–knockout mice …