Development of a Heat-Killed fbp1 Mutant Strain as a Therapeutic Agent To Treat Invasive Cryptococcus Infection
In previous studies, we determined that the F-box protein Fbp1, a subunit of the SCF (Fbp1)
E3 ligase in Cryptococcus neoformans, is essential for fungal pathogenesis. Heat-killed …
E3 ligase in Cryptococcus neoformans, is essential for fungal pathogenesis. Heat-killed …
A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model
Cryptococcus neoformans is a fungal pathogen that infects the lungs and then often
disseminates to the central nervous system, causing meningitis. How Cryptococcus is able …
disseminates to the central nervous system, causing meningitis. How Cryptococcus is able …
Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes
Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly
C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no …
C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no …
Fbp1-mediated ubiquitin-proteasome pathway controls Cryptococcus neoformans virulence by regulating fungal intracellular growth in macrophages
TB Liu, C Xue - Infection and immunity, 2014 - Am Soc Microbiol
Cryptococcus neoformans is a human fungal pathogen that often causes lung and brain
infections in immunocompromised patients, with a high fatality rate. Our previous results …
infections in immunocompromised patients, with a high fatality rate. Our previous results …
Insights into the Mechanisms of Protective Immunity against Cryptococcus neoformans Infection Using a Mouse Model of Pulmonary Cryptococcosis
KL Wozniak, S Ravi, S Macias, ML Young… - PloS one, 2009 - journals.plos.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
pneumonia and meningoencephalitis in immune compromised individuals. Previous studies …
pneumonia and meningoencephalitis in immune compromised individuals. Previous studies …
Induction of protective immunity to cryptococcal infection in mice by a heat-killed, chitosan-deficient strain of Cryptococcus neoformans
R Upadhya, WC Lam, B Maybruck, CA Specht… - MBio, 2016 - Am Soc Microbiol
Cryptococcus neoformans is a major opportunistic fungal pathogen that causes fatal
meningoencephalitis in immunocompromised individuals and is responsible for a large …
meningoencephalitis in immunocompromised individuals and is responsible for a large …
The F-Box Protein Fbp1 Shapes the Immunogenic Potential of Cryptococcus neoformans
Cryptococcus neoformans is the main etiologic agent of cryptococcal meningitis and causes
a significant number of deadly infections per year. Although it is well appreciated that host …
a significant number of deadly infections per year. Although it is well appreciated that host …
TNF-α-Producing Cryptococcus neoformans Exerts Protective Effects on Host Defenses in Murine Pulmonary Cryptococcosis
Z Fa, J Xu, J Yi, J Sang, W Pan, Q Xie, R Yang… - Frontiers in …, 2019 - frontiersin.org
Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal
infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic …
infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic …
Three Models of Vaccination Strategies Against Cryptococcosis in Immunocompromised Hosts Using Heat-Killed Cryptococcus neoformans Δsgl1
TG Normile, M Del Poeta - Frontiers in Immunology, 2022 - frontiersin.org
Vaccines are one of the greatest medical accomplishments to date, yet no fungal vaccines
are currently available in humans mainly because opportunistic mycoses generally occur …
are currently available in humans mainly because opportunistic mycoses generally occur …
Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain
FL Wormley Jr, GM Cox, JR Perfect - Microbial pathogenesis, 2005 - Elsevier
Cryptococcus neoformans is an opportunistic fungal pathogen that threatens individuals with
impaired cell-mediated immunity (CMI). Presently, there are no standardized vaccines …
impaired cell-mediated immunity (CMI). Presently, there are no standardized vaccines …