Matrix metalloproteases in head and neck cancer

EL Rosenthal, LM Matrisian - Head & Neck: Journal for the …, 2006 - Wiley Online Library
Matrix metalloproteases (MMPs) are a collection of enzymes capable of cleaving
extracellular matrix components, growth factors, and cell‐surface receptors. MMPs modulate …

Matrix metalloproteinase-2 as a target for head and neck cancer therapy

MH Chien, CW Lin, CW Cheng, YC Wen… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Matrix metalloproteinase (MMP)-2 is a zinc-dependent proteinase that is
capable of cleaving all extracellular matrix (ECM) substrates. Degradation of the matrix is a …

Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma

SJ Charous, GP Stricklin, JL Netterville… - Annals of Otology …, 1997 - journals.sagepub.com
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes implicated in the
invasion and metastasis of many cancers. In situ hybridization techniques were used to …

Matrix metalloproteinases in head and neck cancer: current perspectives

I Gkouveris, NG Nikitakis, J Aseervatham… - Metalloproteinases In …, 2017 - Taylor & Francis
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24
distinct genes. Their functions have been implicated in numerous normal and pathologic …

Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas

T Görögh, UH Beier, J Bäumken… - Head & Neck …, 2006 - Wiley Online Library
Abstract Background. Matrix metalloproteinases (MMPs) play an important role in tumor
invasiveness. This study investigates the expression status of MMPs and tissue inhibitors of …

Expression of MMPS, MT‐MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis

S Kurahara, M Shinohara, T Ikebe… - Head & Neck …, 1999 - Wiley Online Library
Abstract Background Matrix metalloproteinases (MMPs) that degrade the extracellular
matrices (ECMs) have been thought to play an important role in both the invasion and …

Matrix metalloproteinases: protective roles in cancer

J Decock, S Thirkettle, L Wagstaff… - Journal of cellular and …, 2011 - Wiley Online Library
Introduction• MMP‐3• MMP‐8• MMP‐9• MMP‐12• MMP‐19• MMP‐26• Conclusions The
original notion that matrix metalloproteinases (MMPs) act as tumour and metastasis …

[PDF][PDF] Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell …

Y Imanishi, M Fujii, Y Tokumaru, T Tomita… - Human …, 2000 - researchgate.net
Three different membrane-type matrix metalloproteinases (MT-MMPs) activate in vitro the
latent form of matrix metalloproteinase-2 (MMP-2), which is one of the key proteinases in …

Roles of membrane‐type matrix metalloproteinase‐1 in tumor invasion and metastasis

H Sato, T Takino, H Miyamori - Cancer science, 2005 - Wiley Online Library
Degradation of extracellular matrix (ECM) is one of the first steps in tumor invasion and
metastasis. Matrix metalloproteinases (MMP) have been strongly implicated in this step …

Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck

O Pornchai, PH Rhys-Evans… - … of otolaryngology–head …, 2001 - jamanetwork.com
Background Matrix metalloproteinases (MMPs) have been implicated in the invasion and
metastasis of head and neck squamous cell carcinoma (HNSCC). However, a detailed …