In malignant melanomas, the loss of cell cycle control is thought to be due to a lack of
retinoblastoma protein (pRb)-activity. Members of the previously described family of …

The loss of cell cycle control in malignant melanomas is thought to be due to a lack of
retinoblastoma protein (pRb) activity. We have recently reported a progressive deficiency of …

Using RNA arbitrarily primed PCR, the authors selected for transcripts with cell cycle-related
differential expression in cultured human melanocytes. Among the partial cDNAs cloned, a …

Background: Antibodies isolated from cancer patients have been used to identify genes
encoding tumor-associated antigen epitopes relevant to immune responses in cancer …

We have previously isolated cDNA of a novel protein (RBQ-1, HGMW-approved symbol
RBBP6) that binds to the retinoblastoma gene product (pRB). Total nucleotide sequence of …

The retinoblastoma gene family is composed of three members: the product of the
retinoblastoma gene (pRb), which is one of the most well studied tumor suppressor genes …

Even though the retinoblastoma gene is one of the best-studied tumor suppressor genes,
little is known about its functional role. Like all tumor suppressor gene products, the …

The retinoblastoma susceptibility gene (RB-1) was among the first tumor suppressor genes
to be cloned and has provided many useful paradigms for the study of molecular alterations …

The retinoblastoma tumor-suppressor gene (Rb1) is centrally important in cancer research.
Mutational inactivation of Rb1 causes the pediatric cancer retinoblastoma, while …

Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to
restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent …