Methods of gene inactivation include genetic events such as mutations or deletions.
Epigenetic changes, heritable traits that are mediated by changes in DNA other than …

Epigenetic mechanisms including DNA and histone modifications result in silencing of
genes without changing the coding sequence of the gene. Even though these events are …

It has become apparent over the past several years that one of the attractive emerging
prevention and therapy targets for cancer is the reversal of aberrant gene silencing …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

Epigenetics is the study of mitotically heritable changes in gene expression without any
changes in the primary DNA sequence. The major step in epigenetic gene regulation is …

A cancer develops when a cell acquires specific growth advantages through the stepwise
accumulation of heritable changes in gene function. Basically, this process is directed by …

Epigenetic silencing of tumor suppressor genes is a major contributor to neoplastic
transformation and is an area of intense research. Identification of genes that undergo …

Human cancer represents a heterogeneous group of diseases that are driven by
progressive genetic and epigenetic abnormalities. The latter alterations involve …

Knowledge on heritable changes in gene expression that result from epigenetic events is of
increasing relevance in the development of strategies for prevention, early diagnosis and …

Epigenetic inactivation of genes that are crucial for the control of normal cell growth is a
hallmark of cancer cells. These epigenetic mechanisms include crosstalk between DNA …