Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects
VHJ Van der Velden, A Hochhaus, G Cazzaniga… - Leukemia, 2003 - nature.com
Detection of minimal residual disease (MRD) has prognostic value in many hematologic
malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic …
malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic …
Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia
O Verhagen, MJ Willemse, WB Breunis, AJM Wijkhuijs… - Leukemia, 2000 - nature.com
Large-scale clinical studies on detection of minimal residual disease (MRD) in acute
lymphoblastic leukemia (ALL) have shown that quantification of MRD levels is needed for …
lymphoblastic leukemia (ALL) have shown that quantification of MRD levels is needed for …
MRD detection in acute lymphoblastic leukemia patients using Ig/TCR gene rearrangements as targets for real-time quantitative PCR
VHJ van der Velden, JJM van Dongen - Leukemia: Methods and Protocols, 2009 - Springer
Minimal residual disease (MRD) diagnostics has proven to be clinically relevant for
evaluation of treatment effectiveness in patients with acute lymphoblastic leukemia (ALL). In …
evaluation of treatment effectiveness in patients with acute lymphoblastic leukemia (ALL). In …
Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes
MJ Pongers-Willemse, O Verhagen, GJM Tibbe… - Leukemia, 1998 - nature.com
Abstract Analysis of minimal residual disease (MRD) can predict outcome in acute
lymphoblastic leukemia (ALL). A large prospective study in childhood ALL has shown that …
lymphoblastic leukemia (ALL). A large prospective study in childhood ALL has shown that …
Improved assessment of minimal residual disease in B cell malignancies using fluorogenic consensus probes for real-time quantitative PCR
M Brüggemann, J Droese, I Bolz, P Lüth, C Pott… - Leukemia, 2000 - nature.com
PCR of clonally rearranged immunoglobulin heavy chain (IgH) gene sequences is
increasingly used for detection of minimal residual disease (MRD) in lymphoid …
increasingly used for detection of minimal residual disease (MRD) in lymphoid …
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time'quantitative reverse-transcriptase polymerase …
E Beillard, N Pallisgaard, VHJ Van der Velden, W Bi… - Leukemia, 2003 - nature.com
Real-time quantitative RT-PCR (RQ-PCR) is a sensitive tool to monitor minimal residual
disease (MRD) in leukemic patients through the amplification of a fusion gene (FG) …
disease (MRD) in leukemic patients through the amplification of a fusion gene (FG) …
A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR
J Meijerink, C Mandigers, L van de Locht… - The Journal of Molecular …, 2001 - Elsevier
Quantification of residual disease by real-time polymerase chain reaction (PCR) will become
a pivotal tool in the development of patient-directed therapy. In recent years, various …
a pivotal tool in the development of patient-directed therapy. In recent years, various …
Detection of minimal residual disease in acute leukemia by immunological marker analysis and polymerase chain reaction.
JJ Van Dongen, TM Breit, HJ Adriaansen, A Beishuizen… - Leukemia, 1992 - europepmc.org
Detection of minimal residual disease (MRD) can be useful for adaptation or stratification of
treatment in acute leukemia patients and may finally result in individualization of treatment …
treatment in acute leukemia patients and may finally result in individualization of treatment …
Monitoring of minimal residual disease in acute myeloid leukemia
W Kern, C Schoch, T Haferlach, S Schnittger - Critical reviews in oncology …, 2005 - Elsevier
Monitoring minimal residual disease (MRD) becomes increasingly important in the risk-
adapted management of patients with acute myeloid leukemia (AML). The two most …
adapted management of patients with acute myeloid leukemia (AML). The two most …
Rapid and reliable quantification of minimal residual disease in acute lymphoblastic leukemia using rearranged immunoglobulin and T-cell receptor loci by …
M Nakao, JWG Janssen, T Flohr, CR Bartram - Cancer Research, 2000 - AACR
The detection of minimal residual disease (MRD) using immunoglobulin and T-cell receptor
(TCR) rearrangements as PCR targets provides important prognostic information on the in …
(TCR) rearrangements as PCR targets provides important prognostic information on the in …
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