Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its
progression-free survival. However, current antiangiogenic therapy induces serious adverse …

Malignant gliomas are characterized by a diffuse infiltration into the surrounding brain
parenchyma. Infiltrating glioma cells exist in close proximity with components of the tumor …

Angiogenesis is a promising target for the development of effective strategies for the
treatment of malignant brain tumors in that it has the potential to starve large tumors and …

Background Glioblastoma multiforme (GBM, WHO grade IV) is the most common and most
malignant of astrocytic brain tumors, and is associated with rapid invasion into neighboring …

The invasion of glioblastoma is a complex process based on the interactions of tumor cells
and the extracellular matrix. Tumors that are engineered using biomaterials are more …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

OBJECTIVE Glioblastoma (GBM) is the most malignant primary brain tumor. Collagen is
present in low amounts in normal brain, but in GBMs, collagen gene expression is reportedly …

The lack of an intracranial human glioma model that recapitulates the extensive invasive
and hypervascular features of glioblastoma (GBM) is a major hurdle for testing novel …

Tumor microvasculature tends to be malformed, more permeable, and more tortuous than
vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF …

Glioblastoma multiforme (GBM) are highly invasive and angiogenic malignancies with a
median survival time from diagnosis of< 15 months. Previous work has revealed robust …