The new coating material staves off clotting because its copper ions catalyze the production
of nitric oxide in the blood, says Mark Meyerhoff of the University of Michigan in Ann Arbor. In …

The mainstay in the field of gene delivery has been the use of cationic lipids to complex and
condense plasmid. Poly-L-lysine (PLL) has also attracted much attention, but PLL has …

Objective: Endothelium is an important target for gene therapy. We have investigated the
effect of viral and non-viral vectors on the phenotype and function of endothelial cells (ECs) …

Pathologic lesions caused by catheter-based revascularization procedures for occlusive
artery disease include disruption of the endothelium, exposure of extracellular matrix (ECM) …

For gene therapy, the last few years have been an exciting period. Encouraging results from
several successful gene therapy trials were reported. Children born with a life-threatening …

Increasing the level and duration of transgene expression and restricting expression to
vascular cells are important goals for clinically useful gene therapy vectors. We evaluated …

Atherosclerosis remains the major cause of morbidity and mortality in Western countries.
Atherothrombotic complications, including vascular occlusions and severe narrowing of …

Background: Therapeutic angiogenesis strategies have focused on protracted delivery of
growth factors using gene transfer approaches that are limited by potential toxicitiy and …

Materials and Methods Materials. All cell culture media and buffers were obtained from
Invitrogen (UK) unless otherwise specified. All laboratory chemicals were from Sigma …

Since its inception over three decades ago, the field of angiogenesis has made significant
progress and has led to an improved understanding of physiological and pathophysiological …