For gene therapy, the last few years have been an exciting period. Encouraging results from
several successful gene therapy trials were reported. Children born with a life-threatening …

Background: Drug-eluting stents (DES) have proven to be useful to prevent restenosis.
These ''first-generation''DES, however, have serious problems of delayed healing process …

Background: Therapeutic angiogenesis strategies have focused on protracted delivery of
growth factors using gene transfer approaches that are limited by potential toxicitiy and …

Atherosclerosis remains the major cause of morbidity and mortality in Western countries.
Atherothrombotic complications, including vascular occlusions and severe narrowing of …

Materials and Methods Materials. All cell culture media and buffers were obtained from
Invitrogen (UK) unless otherwise specified. All laboratory chemicals were from Sigma …

The arterial wall is composed of the intima, media, and adventitia. The intima consists of the
endothelium and, in some species, 1-2 layers of SMCs as well (Schwartz et al., 1995a) …

Smooth muscle cell accumulation is a key feature of restenosis that may be inhibited by the
delivery of receptor-targeted cytotoxins. DAB389EGF is a recombinant fusion protein in …

Efforts to stimulate tissue vascularization in patients with ischemia resulting from coronary or
peripheral arterial disease (therapeutic angiogenesis1, 2) have passed through several …

MATERIALS AND METHODS Cell cultures. PC12 cells were grown on collagen-coated
plates in Dulbecco's modified Eagle medium (DMEM) with or without 10% horse serum–5 …