Abstract Purpose of the Review Inflammatory cytokines play a major role in atherosclerotic
plaque progression. This review summarizes the rationale for personalized anti …

Atherosclerosis demonstrates an increased rate of vascular smooth muscle cells (VSMC)
plasticity characterized by switching from the differentiated contractile phenotype to a de …

The notion of atherosclerosis as a chronic inflammatory disease has intensified research on
the role of cytokines and the way these molecules act and interact to initiate and sustain …

Atherosclerosis is a pathological process caused by vascular remodeling. It symbolizes one
of the major causes for morbidity and mortality in the western world. The causes for these …

Inflammation plays a key role in atherothrombosis: in the development of plaques, plaque
rupture and thrombus formation. Various biochemical substances have been shown to be …

The designation of atherosclerosis as a chronic inflammatory process represents an
interesting paradigmatic shift for cardiologists. The plasma concentrations of interleukin-6 …

Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …

Atherosclerosis is now understood to be a disease characterized by inflammation that
results in a host of complications, including ischemia, acute coronary syndromes (unstable …

Inflammation plays a pivotal role in all stages of atherogenesis, from foam cell to plaque
formation to rupture and ultimately to thrombosis. Insight gained from recent basic and …

The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …