In solid tumors, the development of vasculature is, to some extent, slower than the
proliferation of the different types of cells that form the tissue, both cancer and stroma cells …

Abstract Background and Aims Although both cancer and stellate cells (PSCs) secrete
proangiogenic factors, pancreatic cancer is a scirrhous and hypoxic tumor. The impact of …

Solid tumors often contain regions with insufficient oxygen delivery, a condition called
hypoxia. Tumor hypoxia is an independent prognostic factor significantly correlated with …

Epithelial-mesenchymal transition (EMT) is a normal developmental process by which
epithelial cells lose their polarity and cell-cell adhesions to become more motile and …

A population of stromal cells, myeloid‐derived suppressor cells (MDSCs), is present in
tumors. Though studies have gradually revealed the protumorigenic functions of MDSCs, the …

Abstract Cancer Stem Cells (CSCs) are an inconspicuous subpopulation of cells found in
solid tumors that is responsible for tumor heterogeneity, therapeutic resistance, and relapse …

Objectives: In the last AACR meeting, we reported that CD133 as a marker of cancer stem
cells (CSCs) plays an important role in tumorigenesis of a pancreatic cancer cell line, Capan …

Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often
resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced …

Tumor tissue is composed of both cancer cells and stromal cells recruited from normal
tissue. These cells include fibroblastic cells, endothelial cells, and cells of hematopoietic …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal reaction
(desmoplasia). We have previously reported that mice with conditional Kras G12D mutation …