Background Gastric cancer (GC) is one of the most common causes of cancer death.
Hypoxia is an important property of the tumor microenvironment of GC. Increasing evidence …

Cancer stem cells (CSCs), a subpopulation possess tumor initiation and self-renewal
capacity, are responsible for recurrence, metastases and drug resistance. Thus, it is …

Cancer-associated fibroblasts (CAFs) have been considered to play an important role for
tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in …

INTRODUCTION: Pancreatic cancer is characterized by extraordinary fibrosis and
pancreatic stellate cells (PSCs) are the major player in synthesizing extracellular matrix …

Pancreatic adenocarcinoma (PDAC) is a cancer particularly resistant to current therapies.
One possible reason consists in its cellular composition that limits access to drugs. Indeed …

Pancreatic cancer is one of the leading causes of death worldwide among all cancer types
due to difficulty detecting in early-stages of disease. Poor understanding of the mediators …

Stomach cancer shows multiple gene changes, including both oncogenes and tumor
suppressor genes. Among them, the one most frequently implicated in stomach cancer is the …

Objective Toinvestigatetheeffectoftumorrstromacrosst… (Hscs). Methods
HumanhepatomacelllinesHepG2, Hep3B, andHuh7andtheHscLXr2wereculturedsepar …

Stromal cells are one of the important components of tumor mieroenvironment, which plays
an oncogenic role in tumorigenesis. Stromai cells and their products can transform adjacent …

Cancer stem cells (CSCs) which are known to be residing deep inside the core of the tumor
in its hypoxia niche is responsible for relapse of cancers. Owing to this hypoxic niche, the …