Cultured rat mesangial cells have features of immune effector cells that may contribute to the
derangements in glomerulonephritis. Recent reports have demonstrated that mesangial …

Abstract Interleukin-4 (IL-4) has been recently implicated in the pathogenesis of
glomerulonephritis. However, the expression of IL-4 and IL-4 receptor (IL-4R) in human …

Abstract Interleukin-1 (IL-1) is a powerful proinflammatory cytokine whose function is
modulated by a natural IL-1 receptor antagonist (IL-1ra). There are few data about kinetics of …

Glomerular mesangial cell (MC)--derived IL-1 may be an important factor in the development
of the hypercellularity and sclerosis characteristic of many forms of glomerulonephritis. To …

Conditioned media from LPS-activated rat peritoneal macrophages enhanced the
proliferation rates of cultured rat glomerular mesangial cells. This macrophage-derived …

To investigate the role of cytokines in the pathogenesis of experimental glomerulonephritis
(GN), we examined interleukin 1 (IL-1) activity in isolated glomeruli of rats with an …

The proteins expressing interleukin 1 (IL 1) activity from rat peritoneal macrophages and
cultured glomerular mesangial cells were compared after purification to apparent …

IL-1 is a pleiotropic factor encoded for by at least two genes, alpha and beta, and capable of
eliciting a broad set of immunologic and inflammatory events. MRL/MP-lpr (MRL-lpr) mice …

In this study, we demonstrated that IL-6 was a possible autocrine growth factor for rat
mesangial cells (MC). rIL-6 induced in vitro growth of rat MC at a concentration of 2 to 200 …

The capacity of human cultured mesangial cells to produce soluble factors potentially
relevant for mechanisms of inflammation and immunity at the glomerular site was analyzed …