Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?

Y Pashaei - Journal of Clinical Neuroscience, 2021 - Elsevier
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is
undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 …

Overview of the potential use of fluvoxamine for COVID-19 and long COVID

K Hashimoto - Discover Mental Health, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has presented a serious worldwide threat to
public health since its emergence in late 2019. From a safety point of view, drug repurposing …

Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?

LHA Costa, BM Santos, LGS Branco - European journal of pharmacology, 2020 - Elsevier
The absence of a specific treatment for SARS-CoV-2 infection led to an intense global effort
in order to find new therapeutic interventions and improve patient outcomes. One important …

Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for use

VS Foletto, TF Da Rosa, MB Serafin… - European journal of clinical …, 2022 - Springer
Purpose The absence of specific treatments for COVID-19 leads to an intense global effort in
the search for new therapeutic interventions and better clinical outcomes for patients. This …

[HTML][HTML] Neuropsychiatric drugs against COVID-19: What is the clinical evidence?

JK Mueller, P Riederer, WE Müller - Pharmacopsychiatry, 2022 - thieme-connect.com
Since the beginning of the coronavirus disease (COVID)-19 pandemic, the need for effective
treatments for COVID-19 led to the idea of “repurposing” drugs for antiviral treatment …

Opportunities for drug repurposing of serotonin reuptake inhibitors: potential uses in inflammation, infection, cancer, neuroprotection, and Alzheimer's disease …

MJ Nykamp, CF Zorumski, AM Reiersen… - …, 2022 - thieme-connect.com
Serotonin reuptake inhibitors (SRIs) are safe and widely used for a variety of indications
including depressive disorders, anxiety, and chronic pain. Besides inhibiting the serotonin …

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

SM Fred, S Kuivanen, H Ugurlu… - Frontiers in …, 2022 - frontiersin.org
Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …

[HTML][HTML] Efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: a systematic review and meta-analysis

J Deng, D Rayner, HB Ramaraju, U Abbas… - Clinical Microbiology …, 2023 - Elsevier
Background The efficacy of selective serotonin reuptake inhibitors (SSRIs) in the treatment
of acute COVID-19 is still under investigation, with conflicting results reported from …

Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19

M Mahdi, L Hermán, JM Réthelyi, BL Bálint - International Journal of …, 2022 - mdpi.com
Mapping non-canonical cellular pathways affected by approved medications can accelerate
drug repurposing efforts, which are crucial in situations with a global impact such as the …

[HTML][HTML] Repurposing selective serotonin reuptake inhibitors for severity of COVID-19: a population-based study

I Visos-Varela, M Zapata-Cachafeiro… - European …, 2023 - Elsevier
Abstract The World Health Organization has proposed that a search be made for alternatives
to vaccines for the prevention and treatment of COVID-19, with one such alternative being …