Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Inflammation plays a pivotal role in all stages of atherogenesis, from foam cell to plaque
formation to rupture and ultimately to thrombosis. Insight gained from recent basic and …

Atherosclerosis is now understood to be a disease characterized by inflammation that
results in a host of complications, including ischemia, acute coronary syndromes (unstable …

Atherosclerosis is a chronic inflammatory process and both the innate and adaptive immune
systems 1 play central roles in its initiation and subsequent progression. 2 Experimental …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Background Inflammation links to atherosclerosis and its complications in various
experimental investigations. Animal studies have implicated numerous inflammatory …

It is now generally recognized that atherosclerosis is a chronic inflammatory disease,
characterized by overrecruitment of leukocytes (monocytes and T-cells) to the site of …

Atherosclerosis represents the most common pathological substrate of coronary heart
disease (CHD), and the characterization of the disease as a chronic low-grade inflammatory …

The concept of the involvement of inflammation in the pathogenesis of atherosclerosis has
existed since the 1800s, stemming from sentinel pathologic observations made by Rudolf …

Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …