Diffusion and directed motion in cellular transport

A Caspi, R Granek, M Elbaum - Physical Review E, 2002 - APS
We study the motion of a probe driven by microtubule-associated motors within a living
eukaryotic cell. The measured mean square displacement,< x (t) 2> of engulfed 2 and 3 μ m …

Enhanced diffusion in active intracellular transport

A Caspi, R Granek, M Elbaum - Physical review letters, 2000 - APS
We show that within a living eukaryotic cell, mean square displacement of an engulfed
microsphere shows enhanced diffusion scaling as t 3/2 at short times, with a clear crossover …

Temporal analysis of active and passive transport in living cells

D Arcizet, B Meier, E Sackmann, JO Rädler… - Physical review letters, 2008 - APS
The cellular cytoskeleton is a fascinating active network, in which Brownian motion is
intercepted by distinct phases of active transport. We present a time-resolved statistical …

Intracellular transport by active diffusion

CP Brangwynne, GH Koenderink, FC MacKintosh… - Trends in cell …, 2009 - cell.com
All substances exhibit constant random motion at the microscopic scale. This is a direct
consequence of thermal agitation, and leads to diffusion of molecules and small particles in …

Molecular motors pulling cargos in the viscoelastic cytosol: how power strokes beat subdiffusion

I Goychuk, VO Kharchenko, R Metzler - Physical Chemistry Chemical …, 2014 - pubs.rsc.org
The discovery of anomalous diffusion of larger biopolymers and submicron tracers such as
endogenous granules, organelles, or virus capsids in living cells, attributed to the …

Mechanics of single cells: rheology, time dependence, and fluctuations

G Massiera, KM Van Citters, PL Biancaniello… - Biophysical …, 2007 - cell.com
The results of mechanical measurements on single cultured epithelial cells using both
magnetic twisting cytometry (MTC) and laser tracking microrheology (LTM) are described …

Local motion analysis reveals impact of the dynamic cytoskeleton on intracellular subdiffusion

M Otten, A Nandi, D Arcizet, M Gorelashvili, B Lindner… - Biophysical journal, 2012 - cell.com
Intracellular transport is a complex interplay of ballistic transport along filaments and of
diffusive motion, reliably delivering material and allowing for cell differentiation, migration …

Anomalous diffusion of single particles in cytoplasm

BM Regner, D Vučinić, C Domnisoru, TM Bartol… - Biophysical journal, 2013 - cell.com
The crowded intracellular environment poses a formidable challenge to experimental and
theoretical analyses of intracellular transport mechanisms. Our measurements of single …

Anomalous transport in the crowded world of biological cells

F Höfling, T Franosch - Reports on Progress in Physics, 2013 - iopscience.iop.org
A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …

How molecular motors work in the crowded environment of living cells: coexistence and efficiency of normal and anomalous transport

I Goychuk, VO Kharchenko, R Metzler - PloS one, 2014 - journals.plos.org
Recent experiments reveal both passive subdiffusion of various nanoparticles and
anomalous active transport of such particles by molecular motors in the molecularly crowded …