Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4 (3H) quinazolinone analogues
IA Al-Suwaidan, AAM Abdel-Aziz… - Journal of enzyme …, 2016 - Taylor & Francis
A novel series of 3-benzyl-substituted-4 (3 H)-quinazolinones were designed, synthesized
and evaluated for their in vitro antitumor activity. The results of this study demonstrated that 2 …
and evaluated for their in vitro antitumor activity. The results of this study demonstrated that 2 …
Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues
AS El-Azab, AAM Abdel-Aziz… - Journal of Enzyme …, 2017 - Taylor & Francis
A novel series of 2-substituted mercapto-3-(3, 4, 5-trimethoxybenzyl)-4 (3H)-quinazolinones
1–20 was synthesised and evaluated for in vitro antitumour activity. N-(4-Chlorophenyl)-2-[(3 …
1–20 was synthesised and evaluated for in vitro antitumour activity. N-(4-Chlorophenyl)-2-[(3 …
Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies
AM Alanazi, AAM Abdel-Aziz, TZ Shawer… - Journal of Enzyme …, 2016 - Taylor & Francis
Some new derivatives of substituted-4 (3 H)-quinazolinones were synthesized and
evaluated for their in vitro antitumor and antimicrobial activities. The results of this study …
evaluated for their in vitro antitumor and antimicrobial activities. The results of this study …
2-(Chloromethyl)-3-phenylquinazolin-4 (3H)-ones as potent anticancer agents; cytotoxicity, molecular docking and in silico studies
In order to show antiproliferation and cancerous cell growth inhibition of quinazoline
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …
Synthesis and evaluation of new 4 (3H)-Quinazolinone derivatives as potential anticancer agents
A series of new 4 (3H)-quinazolinones were synthesized and evaluated for their cytotoxic
activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 …
activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 …
Design, synthesis, characterization, enzymatic inhibition evaluations, and docking study of novel quinazolinone derivatives
K Pedrood, M Sherafati… - International Journal of …, 2021 - Elsevier
In this study, novel quinazolinone derivatives 7a-n were synthesized and evaluated against
metabolic enzymes including α-glycosidase, acetylcholinesterase, butyrylcholinesterase …
metabolic enzymes including α-glycosidase, acetylcholinesterase, butyrylcholinesterase …
Synthesis and screening of 2-(2-(4-substituted piperazine-1-yl)-5-phenylthiazol-4-yl)-3-aryl quinazolinone derivatives as anticancer agents
RN Sharma, R Ravani - Medicinal Chemistry Research, 2013 - Springer
Synthesis of novel quinazolinone derivatives was performed from the reaction of N-benzoyl
substituted piperazine-1-carbothioamide with 2-chloromethyl quinazolinone derivatives and …
substituted piperazine-1-carbothioamide with 2-chloromethyl quinazolinone derivatives and …
Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
Y Le, Y Gan, Y Fu, J Liu, W Li, X Zou… - Journal of enzyme …, 2020 - Taylor & Francis
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed,
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
Design, synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: molecular docking study
IA Al-Suwaidan, AM Alanazi, AM Alaa… - Bioorganic & medicinal …, 2013 - Elsevier
A novel series of 2-(3-phenethyl-4 (3H) quinazolin-2-ylthio)-N-substituted anilide and
substituted phenyl 2-(3-phenethyl-4 (3H) quinazolin-2-ylthio) acetate were designed …
substituted phenyl 2-(3-phenethyl-4 (3H) quinazolin-2-ylthio) acetate were designed …
Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities
AS El-Azab, KEH ElTahir - Bioorganic & medicinal chemistry letters, 2012 - Elsevier
A novel series of 7-substituted-4 (3H)-quinazolinone were designed, synthesized and
evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad …
evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad …