The role of cell surface sialic acids for SARS-CoV-2 infection

XL Sun - Glycobiology, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a new virus that has
higher contagious capacity than any other previous human coronaviruses (HCoVs) and …

Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2

W Saso, M Yamasaki, S Nakakita, S Fukushi… - PLoS …, 2022 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been transmitted
across all over the world, in contrast to the limited epidemic of genetically-and virologically …

Coronaviruses: is sialic acid a gate to the eye of cytokine storm? From the entry to the effects

P Wielgat, K Rogowski, K Godlewska, H Car - Cells, 2020 - mdpi.com
Coronaviruses (CoVs) are a diverse family of the enveloped human and animal viruses
reported as causative agents for respiratory and intestinal infections. The high pathogenic …

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

L Nguyen, KA McCord, DT Bui, KM Bouwman… - Nature Chemical …, 2022 - nature.com
Emerging evidence suggests that host glycans influence severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. Here, we reveal that the receptor-binding domain …

[HTML][HTML] Subtle influence of ACE2 glycan processing on SARS-CoV-2 recognition

JD Allen, Y Watanabe, H Chawla, ML Newby… - Journal of molecular …, 2021 - Elsevier
The severity of SARS-CoV-2 infection is highly variable and yet the molecular basis for this
effect remains elusive. One potential contribution are differences in the glycosylation of …

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

SJL Petitjean, W Chen, M Koehler, R Jimmidi… - Nature …, 2022 - nature.com
The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent
need to better understand the molecular details of the virus binding to its host cell and to …

SARS-CoV-2 evolutionary adaptation toward host entry and recognition of receptor O-Acetyl sialylation in virus–host interaction

CH Kim - International journal of molecular sciences, 2020 - mdpi.com
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus
disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into …

Bioinformatics studies on a function of the SARS-CoV-2 spike glycoprotein as the binding of host sialic acid glycans

B Robson - Computers in biology and medicine, 2020 - Elsevier
Abstract SARS-CoV and SARS-CoV-2 do not appear to have functions of a hemagglutinin
and neuraminidase. This is a mystery, because sugar binding activities appear essential to …

Sialylated glycan bindings from SARS-CoV-2 spike protein to blood and endothelial cells govern the severe morbidities of COVID-19

DE Scheim, P Vottero, AD Santin, AG Hirsh - International journal of …, 2023 - mdpi.com
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …

Comprehensive characterization of N-and O-glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2

A Shajahan, S Archer-Hartmann, NT Supekar… - …, 2021 - academic.oup.com
The emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created the need for …