To investigate the involvement of reactive oxygen species (ROS) in neuronal apoptosis, we
performed confocal and flow cytometric analysis with a ROS-specific fluorogen, 6-carboxy …

Apoptosis is characterized by chromatin condensation, phosphatidylserine translocation,
and caspase activation. Neuronal apoptotic death involves the participation of reactive …

Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor
(NGF). We used this model of programmed cell death to study the mechanisms that mediate …

The endoplasmic reticulum (ER), which plays important roles in apoptosis, is susceptible to
oxidative stress. Because reactive oxygen species (ROS) are robustly produced in the …

Within the central nervous system and under normal conditions, nitric oxide (NO) is an
important physiological signaling molecule. When produced in large excess, NO also …

The aim of this study was to investigate the relationship between cell cycle reentry and
apoptosis in cultured cortical neurons following oxygen–glucose deprivation (OGD). We …

Oxygen-induced cell death in embryonic neurons is a useful in vitro model of neuronal
apoptosis to study the molecular mechanisms underlying the cell death induced by oxidative …

The endoplasmic reticulum (ER), which plays a role in apoptosis, is susceptible to oxidative
stress. Because superoxide is produced in the brain after ischemia/reperfusion, oxidative …

Oxidative stress-induced neuronal cell death requires opening of the mitochondrial
permeability transition pore. P53 mitochondrial translocation and association with …

We previously reported that PC12h cells are killed by a high oxygen atmosphere. In this
study, we further characterized this oxygen-induced cell death and found apoptotic features …