The term epigenetics refers to the study of heritable changes in phenotype or expression of
genes that are not due to changes in the sequence of DNA. 1 Research into epigenetics has …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

It is well known that a variety of genetic changes influence the development and progression
of cancer. These changes may result from inherited or spontaneous mutations that are not …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

Abstract Changes in DNA methylation profiles are common features of development and in a
number of human diseases, such as cancer and imprinting disorders like Beckwith …

This review focuses on the mechanisms of DNA methylation, DNA methylation pattern
formation and their involvement in gene regulation. Association of DNA methylation with …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

DNA methylation is an important part of the epigenetic code governing gene expression. In
human reproductive diseases, recent studies have shown the existence of deviations from …

Our basic concepts of segregation and assortment of two alleles of a gene have been
shaped by the work of Gregor Mendel [n1]. Similarly, our notions of genetic disorders were …