Current treatments for inoperable mesothelioma: indirect comparisons based on individual patient data reconstructed retrospectively from 4 trials

A Messori, S Trippoli - Journal of Chemotherapy, 2023 - Taylor & Francis
In inoperable pleural mesothelioma, pemetrexed+ cisplatin as first line is considered the
standard of care, but novel treatments have been recently proposed. Our objective was to …

Systemic treatments for mesothelioma: standard and novel

HL Kindler - Current treatment options in oncology, 2008 - Springer
Opinion statement Systemic therapy is the only treatment option for the majority of
mesothelioma patients, for whom age, co-morbid medical illnesses, non-epithelial histology …

Current options for systemic therapy in mesothelioma

DM Jackman - Seminars in thoracic and cardiovascular surgery, 2009 - Elsevier
Systemic therapy options for patients with mesothelioma remain limited. Although many
conventional chemotherapeutic agents have shown modest activity in this disease, only the …

Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label …

Q Chu, F Perrone, L Greillier, W Tu, MC Piccirillo… - The Lancet, 2023 - thelancet.com
Background Pleural mesothelioma usually presents at an advanced, incurable stage.
Chemotherapy with platinum–pemetrexed is a standard treatment. We hypothesised that the …

Clinical trials eligibility of patients with malignant pleural mesothelioma: use of novel therapies and outcomes

B Lau, M Boyer, JH Lee, S Kao - Clinical Lung Cancer, 2020 - Elsevier
Introduction Studies of bevacizumab and pembrolizumab in the treatment of malignant
pleural mesothelioma suggest anticancer efficacy; clinical trial populations are not reflective …

Management of advanced pleural mesothelioma—at the crossroads

AK Nowak, A Jackson, C Sidhu - JCO Oncology Practice, 2022 - ascopubs.org
The management of pleural mesothelioma has changed with the demonstration that first-line
checkpoint blockade therapy improves survival. This review covers issues of relevance to …

Efficacy of phase 1 trials in malignant pleural mesothelioma: description of a series of patients at a single institution

J Raphael, G Le Teuff, A Hollebecque, C Massard… - Lung Cancer, 2014 - Elsevier
Background Malignant pleural mesothelioma (MPM) is a locally aggressive disease with a
poor prognosis. After failure of first line platinum-based chemotherapy, there is no widely …

[HTML][HTML] A real-world analysis of the use of systemic therapy in malignant pleural mesothelioma and the differential impacts on overall survival by practice pattern

K Kerrigan, Y Jo, J Chipman, B Haaland, S Puri… - JTO Clinical and …, 2022 - Elsevier
Introduction Malignant pleural mesothelioma (MPM) is an aggressive malignancy that affects
older adults with frequent comorbidities, making real-world treatment decisions challenging …

Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma

A Guazzelli, E Bakker, K Tian… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Malignant mesothelioma is a rare and lethal malignancy primarily affecting the
pleura and peritoneum. Mesothelioma incidence is expected to increase worldwide and …

A review of pharmacologic management in the treatment of mesothelioma

EP Borrelli, CG McGladrigan - Current Treatment Options in Oncology, 2021 - Springer
Opinion statement Mesothelioma is a rare and severe form of cancer that is associated with
asbestos exposure. Approximately 2500 Americans die annually from this condition with a …