Extensive research has been conducted over several decades understanding the genetic
changes that occur in normal cells to promote them towards a transformed state. However, it …

Malignant transformation of an epithelium occurs within the context of a dynamically
evolving tissue stroma that is composed of multiple cell types surrounded by an extracellular …

In the past 25 years, a majority of cancer studies have focused on examining functional
consequences of activating and/or inactivating mutations in critical genes implicated in cell …

Although the stroma within carcinogenic lesions is known to be supportive and responsive to
tumors, new data increasingly show that the stroma also has a more active, oncogenic role …

The majority of studies of neoplastic transformation have focused attention on events that
occur within transformed cells. These cell autonomous events result in the disruption of …

The importance of stromal cells and the factors that they express during cancer initiation and
progression has been highlighted by recent literature. The cellular components of the stroma …

Numerous studies have demonstrated that the tumor microenvironment not only responds to
and supports carcinogenesis, but also actively contributes to tumor initiation, progression …

The role of tumor stroma in progression to malignancy has become the subject of intense
experimental and clinical interest. The stromal compartment of organs is composed of all the …

An increasing body of research indicates that stroma surrounding cancer cells plays an
important role in the development and subsequent behavior of the tumor. Studies using a …

During tumorigenesis, reciprocal changes in stromal fibroblasts and tumor cells induce
changes to the neoplastic microenvironmental landscape. In stromagenesis, both the …